Histopathology in H&N pathologies in the third millennium

Vol. 117: Issue 2 - April 2025

Head and neck hematolymphoid proliferations: what is new?

Authors

Silvia Varricchio , Rosaria Cappiello , Francesca Magnoli , Daniela Russo , Giovanna Motta , Clara Bertuzzi , Elena Sabattini , Gennaro Ilardi , Mariarosaria Cervasio , Claudia Giordano , Alessandro Severino , Marco Picardi , Massimo Mascolo

Key words: head and neck, World Health Organization, hematolymphoid proliferations and non-neoplastic conditions
Publication Date: 2025-05-21

Abstract

In 2024, the World Health Organization published its 5th edition of tumor classification, which comprises several updates and modifications in the “blue book” focused on head and neck tumors. These changes feature a systematized and expanded discussion on haematolymphoid proliferations using a multi-parameter approach that comprises clinical features, morphology, immunophenotype, and genetic data, with the latter becoming an essential characteristic for classification. Moreover, for the first time, the World Health Organization has included non-neoplastic diseases, such as reactive lymphoid proliferations, alongside several recognized independent disorders, including Epstein-Barr Virus positive mucocutaneous ulcers and IgG4-related diseases. Also, various neoplastic diseases, such as paediatric-type follicular lymphoma and large B-cell lymphoma with IRF4 rearrangement, are recognized as independent entities. Finally, the focus has expanded to include different types of histiocytic neoplasms. This review examines and illustrates the main changes and updates on hematolymphoid proliferation and neoplasia in the Head and Neck chapter of the 5th Edition of the Head and Neck WHO classification.

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Authors

Silvia Varricchio - Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

Rosaria Cappiello - Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

Francesca Magnoli - Unit of Oral Medicine and Pathology, Dental Clinic, Azienda Socio-Sanitaria Territoriale dei Sette Laghi, Varese, Italy

Daniela Russo - Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

Giovanna Motta - Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

Clara Bertuzzi - Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

Elena Sabattini - Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

Gennaro Ilardi - Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

Mariarosaria Cervasio - Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

Claudia Giordano - Department of Clinical Medicine and Surgery, Hematology Section, University of Naples Federico II, Naples, Italy

Alessandro Severino - Department of Clinical Medicine and Surgery, Hematology Section, University of Naples Federico II, Naples, Italy

Marco Picardi - Department of Clinical Medicine and Surgery, Hematology Section, University of Naples Federico II, Naples, Italy

Massimo Mascolo - Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright

Copyright (c) 2025 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology

How to Cite
Varricchio, S., Cappiello, R., Magnoli, F., Russo, D., Motta, G., Bertuzzi, C., Sabattini, E., Ilardi, G., Cervasio, M., Giordano, C., Severino, A., Picardi, M., & Mascolo, M. (2025). Head and neck hematolymphoid proliferations: what is new? . Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology, 117(2). Retrieved from https://www.pathologica.it/article/view/1207
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