Guidelines

Vol. 117: Issue 2 - Suppl. 1 April 2025

Molecular Testing in Solid Tumors: Best Practices from the Molecular Pathology and Precision Medicine Study Group of the Italian Society of Pathology (PMMP/SIAPeC)

Shaping Excellence in Molecular Diagnostics

Authors

Key words: Pathology, recommendations,, molecular diagnostics, precision medicine, standardization
Publication Date: 2025-05-09

Abstract

The Italian Society of Pathology’s Molecular Pathology and Precision Medicine Study Group (PMMP/SIAPeC) has released a three-part set of best practice guidelines to standardize and enhance molecular testing in solid tumors. Part I focuses on the pre-analytical phase, emphasizing proper tissue handling and quality control to preserve nucleic acid integrity. Part II addresses the analytical phase, outlining workflows for next-generation sequencing (NGS), from extraction to variant interpretation, with recommendations on platform choice, gene panels, and bioinformatics. Part III covers the post-analytical phase, offering guidance on structured, clinically meaningful reporting to support therapeutic decisions, including standards for both tissue and liquid biopsies. Together, these documents aim to harmonize molecular diagnostics across Italy, ensuring reliable, high-quality results that support precision oncology.

Downloads

Authors

Nicola Fusco - Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy https://orcid.org/0000-0002-9101-9131

Giancarlo Pruneri - Fondazione IRCCS Istituto Nazionale dei Tumori

Fabio Pagni - University of Milano-Bicocca

Umberto Malapelle - University of Naples Federico II https://orcid.org/0000-0003-3211-9957

How to Cite
Fusco, N., Pruneri, G., Pagni, F., & Malapelle, U. (2025). Molecular Testing in Solid Tumors: Best Practices from the Molecular Pathology and Precision Medicine Study Group of the Italian Society of Pathology (PMMP/SIAPeC): Shaping Excellence in Molecular Diagnostics. Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology, 117(2 (Suppl. 1). Retrieved from https://www.pathologica.it/article/view/1214
  • Abstract viewed - 20 times
  • PDF downloaded - 9 times