Guidelines

Vol. 117: Issue 2 - Suppl. 1 April 2025

Part I – Pre-analytical phase

Authors

Caterina Marchiò , Enrico Berrino , Stefania Scarpino , Greta Alì , Sara Erika Bellomo , Simonetta Buglioni , Andrea Capece , Eliano Cascardi , Giovanni Di Lorenzo , Elena Guerini-Rocco , Antonio Iaccarino , Marzia Nieddu , Daniela Nobilio , Pasquale Pisapia , Leonardo Tonelli , Gianluca Witel , Anna Sapino , Fabio Pagni , Nicola Fusco , Giancarlo Pruneri , Umberto Malapelle

Publication Date: 2025-05-09

Abstract

Precision oncology relies on pathology to integrate morphological and genomic data for tailored treatment selection. The preanalytical phase, covering all steps from specimen collection to processing before analysis, is one of the major determinants of the quality of downstream molecular analyses, which are essential for selection personalized therapeutic strategies. Strict adherence to protocols and specific quality control programs are essential to ensure the reliability and standardization of molecular testing. This document intends to guide the multidisciplinary team (pathologists, technicians, molecular biologists) in pathology laboratories during the preparation of samples for molecular analyses.

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Authors

Caterina Marchiò - University of Turin

Enrico Berrino - , Candiolo Cancer Institute - FPO - IRCCS https://orcid.org/0000-0001-6728-5619

Stefania Scarpino - Sapienza University of Rome https://orcid.org/0009-0009-9668-9626

Greta Alì - University of Pisa https://orcid.org/0000-0001-9258-3466

Sara Erika Bellomo - Candiolo Cancer Institute - FPO - IRCCS https://orcid.org/0000-0001-5738-2351

Simonetta Buglioni - IFO

Andrea Capece - ASL Teramo https://orcid.org/0009-0000-0305-1688

Eliano Cascardi - Candiolo

Giovanni Di Lorenzo - IRCCS Burlo Garofolo https://orcid.org/0009-0006-5587-2705

Elena Guerini-Rocco - IEO

Antonio Iaccarino - Federico II

Marzia Nieddu - Santo Spirito" Hospital, Pescara https://orcid.org/0009-0001-4358-7492

Daniela Nobilio - Santo Spirito" Hospital, Pescara https://orcid.org/0009-0009-8027-8814

Pasquale Pisapia - Federico II https://orcid.org/0000-0002-6429-0620

Leonardo Tonelli - Candiolo https://orcid.org/0009-0004-1670-4982

Gianluca Witel - Candiolo https://orcid.org/0009-0007-7559-3073

Anna Sapino - University of Turin

Fabio Pagni - University of Milano Bicocca

Nicola Fusco - European Institute of Oncology

Giancarlo Pruneri - Fondazione IRCCS Istituto Nazionale dei Tumori

Umberto Malapelle - University of Naples Federico II

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Copyright

Copyright (c) 2025 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology

How to Cite
Marchiò, C., Berrino, E., Scarpino, S., Alì, G., Bellomo, S. E., Buglioni, S., Capece, A., Cascardi, E., Di Lorenzo, G., Guerini-Rocco, E., Iaccarino, A., Nieddu, M., Nobilio, D., Pisapia, P., Tonelli, L., Witel, G., Sapino, A., Pagni, F., Fusco, N., Pruneri, G., & Malapelle, U. (2025). Part I – Pre-analytical phase. Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology, 117(2 (Suppl. 1). Retrieved from https://www.pathologica.it/article/view/1215
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