Abstract

Leiomyosarcoma is a rare malignant mesenchymal tumor characterized by smooth muscle differentiation. It typically arises in both visceral and somatic soft tissues, while involvement of bone being exceptionally uncommon. Although primary leiomyosarcoma of bone has been a subject of ongoing debate, the advent of immunohistochemistry has reduced the misclassification of other sarcomas, such as fibrosarcoma and undifferentiated pleomorphic sarcoma, facilitating the accurate identification of true primary LMSB cases. To date, just over 200 well-documented LMSB cases have been published in English-language literature. Despite this, understanding of its clinical behaviour and factors influencing patient outcomes remains limited. In this study, we present the clinical, pathological, and immunohistochemical findings from 142 cases of primary bone leiomyosarcoma including extended follow-up data.

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Authors

Elena Bellan - Department of Integrated Diagnostics, Azienda Ospedale-Università Padova

Alberto Righi - Department of Pathology, IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy

Marco Gambarotti - Department of Pathology, IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy

Stefania Benini - Epidemiology and Statistics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

Dino Gibertoni - Epidemiology and Statistics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

Marilena Cesari - Osteoncology, Soft Tissue and Bone Sarcomas, Innovative Therapy Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

Giuseppe Bianchi - Unit of 3rd Orthopaedic and Traumatologic Clinic Prevalently Oncologic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

Piero Picci - Department of Pathology, IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy

Angelo Paolo Dei Tos - Department of Medicine, University of Padua School of Medicine, Padua, Italy

Marta Sbaraglia - Department of Medicine, University of Padua School of Medicine, Padua, Italy

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Copyright (c) 2025 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology

How to Cite
Bellan, E., Righi, A., Gambarotti, M., Benini, S., Gibertoni, D., Cesari, M., Bianchi, G., Picci, P., Dei Tos, A. P., & Sbaraglia, M. (2025). Primary Leiomyosarcoma of Bone: A Clinicopathologic and Immunohistochemical Study of 142 Cases. Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology, 117(3). https://doi.org/10.32074/1591-951X-N1251
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