Original articles

Vol. 118: Issue 1 - February 2026

Standardisation of histologic reporting in eosinophilic oesophagitis: Expert recommendations

Authors

Carla Giordano , Valentina Angerilli , Marco Masci , Maria D'Armiento , Paola Parente , Emanuela Pilozzi , Alessandro Vanoli , Salvatore Oliva , Edoardo Vincenzo Savarino , Fassan Matteo , Luca Mastracci

Key words: Eosinophilic oesophagitis, follow-up, histopathology, standardisation, diagnosis
DOI: 10.32074/1591-951X-1842
Publication Date: 2026-03-31

Abstract

Over the past decade, significant progress has been made in understanding eosinophilic oesophagitis (EoE), leading to the refinement of diagnostic criteria and the development of evidence-based management guidelines. Nevertheless, despite the central role of histology in both diagnosis and disease monitoring, significant variability remains in histopathological reporting across institutions and among pathologists.This study seeks to provide recommendations for standardised histological reporting in EoE. To this end, a multidisciplinary panel of gastroenterologists and pathologists convened to review current practices and address persistent challenges in histologic assessment. Through an extensive literature review and critical appraisal of existing scoring systems, the panel reached consensus on both essential and desirable histological features for routine reporting, including eosinophil counts, additional inflammatory parameters, and fibrostenotic changes.

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Authors

Carla Giordano - Department of Radiological, Oncological and Pathological Sciences, Sapienza University

Valentina Angerilli - Physician at Local Health and Social Care Unit Company No. 2 Marca Trevigiana - Ca' Foncello Hospital Treviso (Department of Anatomy and Pathological Histology

Marco Masci - Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy

Maria D'Armiento - Department of Public Health, School of Medicine, University “Federico II”, Naples, Italy

Paola Parente - Unit of Pathology, IRCCS Casa Sollievo della Sofferenza Foundation, San Giovanni Rotondo, Italy

Emanuela Pilozzi - Department of Clinical and Molecular Medicine, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy

Alessandro Vanoli - Department of Molecular Medicine, University of Pavia, Pavia, Italy. Unit of Anatomic Pathology, IRCCS San Matteo Hospital Foundation, Pavia, Italy.

Salvatore Oliva - Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza University of Rome, Rome, Italy.

Edoardo Vincenzo Savarino - Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Fassan Matteo - Department of Medicine (DIMED), University of Padua, Padua, Italy; Veneto Institute of Oncology (IOV.IRCCS), Padua, Italy.

Luca Mastracci - Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy. IRCCS San Martino Policlinic Hospital of Genoa, Genoa, Italy.

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Copyright

Copyright (c) 2026 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology

How to Cite
Giordano, C., Angerilli, V. ., Masci, M., D’Armiento, M., Parente, P. ., Pilozzi, E., Vanoli, A., Oliva, S., Vincenzo Savarino, E., Matteo , F., & Mastracci, L. (2026). Standardisation of histologic reporting in eosinophilic oesophagitis: Expert recommendations. Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology, 118(1). https://doi.org/10.32074/1591-951X-1842
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