Abstract

This letter reports a case of a gestational pemphigoid (GP), a rare autoimmune subepidermal blistering disorder, typically arising in the third trimester of pregnancy. Early-onset presentations, during the first trimester, are exceptionally uncommon and may mimic other pregnancy-related dermatoses, delaying diagnosis. We report a rare early-onset case of GP and discuss the diagnostic challenges and management implications, allowing timely diagnosis and treatment, reducing maternal morbidity and potential obstetric complications.

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Authors

Alessia Di Lorito - SS Annunziata Hospital, Pathology Department, Chieti

Federica Giuliani - Clinic of Dermatology, Department of Medicine and Aging Sciences, University G. d’Annunzio, Chieti, Italy

Edvige Morea - Clinic of Dermatology, Department of Medicine and Aging Sciences, University G. d’Annunzio, Chieti, Italy

Alessandra Capo - Clinic of Dermatology, Department of Medicine and Aging Sciences, University G. d’Annunzio, Chieti, Italy

Paolo Amerio - Clinic of Dermatology, Department of Medicine and Aging Sciences, University G. d’Annunzio, Chieti, Italy

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Copyright (c) 2026 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology

How to Cite
Di Lorito, A., Giuliani, F., Morea, E., Capo, A., & Amerio, P. (2026). Early-onset gestational pemphigoid in the first trimester: a diagnostic pitfall. Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology, 118(1). https://doi.org/10.32074/1591-951X-1943
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