Summary

Calcifying fibrous tumor (CFT) is a rare benign mesenchymal lesion that may exceptionally present as multifocal peritoneal disease, mimicking peritoneal carcinomatosis. We describe a 56-year-old woman presenting with abdominal pain and imaging findings highly suggestive of peritoneal malignancy. However, histological and immunophenotypic evaluation of omental biopsies obtained by diagnostic laparoscopy revealed a multifocal CFT. This case highlights that multifocal calcifying fibrous tumor should be considered in the differential diagnosis of suspected peritoneal carcinomatosis, as recognition of this rare benign entity may prevent misdiagnosis and unnecessary aggressive management.

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Authors

Michele Paudice - Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy

Veronica Parrella - Surgical Pathology Unit, ULSS2 Marca Trevigiana, Treviso, Italy

Luca Valle - IRCCS Azienda Ospedaliera Metropolitana (AOM), Genoa, Italy

Jeries P Zawaideh - RCCS Azienda Ospedaliera Metropolitana (AOM), Genoa, Italy

Nataniele Piol - RCCS Azienda Ospedaliera Metropolitana (AOM), Genoa, Italy

Luca Mastracci - Department of Integrated Diagnostic and Surgical Sciences (DISC), University of Genoa, Genoa, Italy

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Copyright (c) 2026 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology

How to Cite
Paudice, M., Parrella, V., Valle, L., Zawaideh, J. P., Piol, N., & Mastracci, L. (2026). Multifocal calcifying fibrous tumor mimicking peritoneal carcinomatosis. Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology, 118(4). https://doi.org/10.32074/1591-951X-2380
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