Abstract

Gestational choriocarcinoma (GCC) is a malignant and aggressive tumor composed of neoplastic trophoblasts rarely arising months after a normal gestation or after an hydatidiform mole (HM). Histologically, its main diagnostic features are a trimorphic population of trophoblast cells and an absence of chorionic villi. Recently, extremely rare cases of GCC diagnosed in molar and in placenta specimens have been described and accepted as early forms of GCC. We report two cases of GCC diagnosed in a term placenta and in a complete HM (CHM) and underline the importance of recognizing such a rare early form of GCC.

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Authors

Angela Guerriero - Azienda Ospedale Università Padova

Lara Alessandrini - Surgical Pathology Unit, Hospital of Padova, Padova, Italy

Luisa Santoro - Surgical Pathology Unit, Hospital of Padova, Padova, Italy

Kathrin Ludwig - Surgical Pathology Unit, Hospital of Padova, Padova, Italy https://orcid.org/0000-0003-4619-4827

Vennus Shafiei - Surgical Pathology Unit, Hospital of Rovigo, Rovigo, Italy https://orcid.org/0009-0004-4615-0677

Pietro Goglia - Surgical Pathology Unit, Hospital of Padova, Padova, Italy

Pava Srsen - Surgical Pathology Unit, Hospital of Padova, Padova, Italy

Giulia Tasca - Veneto Institute of Oncology, IOV-IRCCS, Padova, Italy

Angelo Paolo Dei Tos - Department of Medicine (DIMED), University of Padova, Padova, Italy

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Copyright (c) 2025 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology

How to Cite
Guerriero, A., Alessandrini, L., Santoro, L., Ludwig, K., Shafiei, V., Goglia, P., Srsen, P., Tasca, G., & Dei Tos, A. P. (2025). Early gestational choriocarcinoma: report of two cases and review of the literature: Early gestational choriocarcinoma. Pathologica - Journal of the Italian Society of Anatomic Pathology and Diagnostic Cytopathology, 117(4). https://doi.org/10.32074/1591-951X-N994
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